The Andy Milonakis Show is a sketch comedy starring Andy Milonakis, which airs on MTV2, the first season having aired on MTV. The show consists of comedy sketches featuring Milonakis as well as a supporting cast made up of his actual neighbors and people from the Lower East Side Manhattan neighborhood where the show takes place, including his friend Ralphie, his neighbor Larry and an old woman called Rifka. Each show also features celebrity guests such as the Ying Yang Twins, Snoop Dogg, Fat Joe, John Stamos, Lil Jon, Rob Schneider, Black Eyed Peas, Biz Markie, Vanessa Minnillo, Juelz Santana, Paul Wall, Nick Cannon, Seth Green, The All-American Rejects, Mike Jones, Carson Daly, Jimmy Kimmel, and Shaun White. Some skits are very short, such as "One Pound," in which Andy slams his fist on a scale.

The show often begins with a cold open, a short sketch to "prepare" the viewer for the rest of the show. For instance, one of these beginning sketches first shows Ralphie behind a drawing of France. Then Andy comes over and says "What ya doing Ralphie" and Ralphie says "I'm Chillin' in Mexico Andy!" Then he says "Shalom".

After the initial sketch and the opening theme--an absurd rap song sung by Andy--the show proceeds to the full-length sketches. Common themes include Andy pretending to know random people, interacting with his neighbors, preparing and eating strange food combinations, and playing with his dog Wubbie. He also orders delivery food and plays jokes on the delivery men, such as making fake coupons, putting shoes in pizzas and asking how they got there, and naming his pizza Larry and assaulting it.

Second Season

The show has been picked up for a second season which airs on MTV2. The second season premiered on March 31, 2006 at 9pm in the Sic'em Friday lineup. Known guest stars are Paul Wall, Mike Jones (who strangles Andy because Andy stole Mike's rhymes), Nick Cannon (who has a "rap battle" that makes each other cry), Juelz Santana, Seth Green, Jimmy Kimmel, and The All-American Rejects (who fly on hovering turtles, roam Andy's house, then leave). The first episode of this season is available for download for Free, on iTunes. As of the second season, the end credits song is no longer American Idiot, but a rap Andy created.

Main Cast:

• Larry: Andy's middle-aged neighbor, who often "borrows" Andy's can openers but doesn't return them.
• Ralphie: Andy's best friend. He shares Andy's penchant for rap and freestyle which started in Season 1.
• Rivka: An old woman who wears four pairs of glasses.
• Billy: A cast member from season two whom appears in some of the show's skits. He is known for his annoyingly loud voice.

Minor Cast:

• Fredia: A middle-aged woman whom likes chicken wings even more than Andy.
• Herbie: Andy's pet turtle who has once been stolen and also can hover.
• Wubbie: Andy's pet dog who sometimes dreams of killing Andy when Andy talks to Wubbie in Baby Talk and laughs when Andy drops Cookies
• Muti: Andy's cousin with a strange speech impediment wherein he can't pronounce the letter "S" correctly, instead, he says "sm".
• Fish Dude: A man who's always holding a fish and smoking a cigarette.